Translating into the new year. A new role for eIF4A and more methyl modifications

Translation, the conversion of the mRNA code into a polypeptide, is a very important process, one that by now you’d think we would have sussed. However, it is the way with science that with further experiments and improvements in techniques, our opinions on cellular mechanisms can change. The process of translation involves hundreds of factors, […]

Trick and TREAT: Visualising mRNA turnover

Gene expression is just part of the story. After transcription, mRNA embarks on a journey out of the nucleus, undergoing many processes along the way, to the cytoplasm where translation can take place. Not all mRNA that is synthesised gets translated into protein, quite a lot of mRNA don’t make it. Instead they get degraded. […]