Slow and steady wins the race: uniting eEF2K, translation and lifespan

Out of all of Aesop’s Fables that I know, which I have now realised isn’t that many, “The tortoise and the hare” was always my favourite as a kid. Whilst the fable has been interpreted in different ways, I always took it to mean that slow and steady wins the race. But what race are […]

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Read More Slow and steady wins the race: uniting eEF2K, translation and lifespan

Putting U in the tail of mRNA

mRNA, the gene transcript that awaits translation, is made of many nucleotides of RNA. These RNA nucleotides can be modified and these modifications can have functional consequences that alters the lifespan of mRNA, its localisation or translation efficiency. Modifications can fall into one of two categories; either nucleotides can be individually targeted or several nucleotides […]

Read More Putting U in the tail of mRNA

Translating into the new year. A new role for eIF4A and more methyl modifications

Translation, the conversion of the mRNA code into a polypeptide, is a very important process, one that by now you’d think we would have sussed. However, it is the way with science that with further experiments and improvements in techniques, our opinions on cellular mechanisms can change. The process of translation involves hundreds of factors, […]

Read More Translating into the new year. A new role for eIF4A and more methyl modifications